The Art of Interpretation
#Genesight will on the one hand diagnose a patient with Homozygous #MTHFR deficiency, and on the other hand, put Tegretol, Trileptal, Lamictal and Depakote in the "Green -aka-Good Category" of medications for the same person. This is why the intelligence is in the individual prescriber's interpretation. Because we can't rely on simple genetic tests with easy to "read" layouts to go the extra mile, in this case understanding that if someone is at a huge risk of a folate deficiency, it's probably in most circumstances not a good idea to put them on some of the most notorious folate-robbers of the medicine cabinet...the anti-epileptics.
Other notorious folate "robbers" can include birth-control pills, ibuprofen, metformin and proton pump inhibitors. There is a good chance many people who are at risk of a folate deficiency are unknowingly taking one or more of these medications. Knowledge, in this case Genetic Knowledge, is power!